Project Goal
Building an atlas of C. elegans worm nuclei in an unsupervised way.
Project Idea:
Consistently matching a large number (100 or more) microscopic worm images with segmented nuclei to each other. The matchings are used in place of ground truth to build the atlas. The project is supported by DFG Projects 98181230 and 53943535 and is run together with Kainmüller Lab in Max Delbrück Center for Molecular Medicine.
Starting Point:
- Building the atlas from partially annotated worm segmentations.
What Was Lacking:
- No fast and accurate enough graph matching (quadratic assignment) solver available — the existing one required ~10 min per worm pair (100×99/2 > 1 month total).
- No fast and accurate enough multi-graph matching solver.
- Supervised pipeline only.
